replication complex造句

• Samatasvir is a highly potent and selective inhibitor of the hepatitis C virus NS5A replication complex.
• Elbasvir is a highly potent and selective NS5A inhibitor of the hepatitis C virus NS5A replication complex.
• Viral protein C binds to replication complex, inducing packaging of new viral positive-stranded DNA into procapsids.
• This suggests that the primary role of the pre-replication complex is to correctly load the Mcm proteins.
• In the assembled replication complex, the clamp encircles the DNA, which passes through the central pore . ]]
• These events are initiated by the formation of the pre-replication complex ( pre-RC ) at the origins of replication.
• The phosphorylation serves two purposes : to activate each already-assembled pre-replication complex, and to prevent new complexes from forming.
• The origin of replication binds the pre-replication complex, a protein complex that recognizes, unwinds, and begins to copy DNA.
• Active S cyclin-CDK complexes phosphorylate proteins that make up the pre-replication complexes assembled during G 1 phase on DNA replication origins.
• The replication complex in coronavirus is also responsible for the synthesis of various mRNAs downstream of ORF 1b, which are structural and accessory proteins.
• This is viable information to have within the article, but there needs to be more information about the different proteins that create the replication complexes.
• It has been suggested that the whole pre-replication complex be called the licensing factor since the whole is required for assembling additional proteins to initiate replication.
• The individual factors described below work together to direct the formation of the pre-replication complex ( pre-RC ), a key intermediate in the replication initiation process.
• The first step in the assembly of the pre-replication complex ( pre-RC ) is the binding of the origin recognition complex ( ORC ) to the replication origin.
• Replication stress is characterized by : increased replication initiation / origin firing; increased transcription and collisions of transcription-replication complexes; nucleotide deficiency; increase in reactive oxygen species ( ROS ).
• In the assembled replication complex, the clamp encircles the DNA, which passes through the central pore, and binds DNA polymerase to prevent the enzyme from dissociating from the template DNA strand.
• The protein encoded by this gene is a key licensing factor which, along with the protein Cdc6, functions to license DNA by forming the pre-replication complex ( pre-RC ).
• Cyclin A has a second function in S phase, in addition to initiating DNA synthesis, Cyclin A ensures that DNA is replicated once per cell cycle by preventing the assembly of additional replication complexes.
• Clb5, in particular, has unique hydrophobic section of amino acids that allows specific interactions with proteins in the pre-replication complex bound on the DNA and helps localize Clb5 to DNA replication origins.
• CRE is the Cis-acting replication element, also known as the 3'SL RNA elements, and is thought to be essential in viral replication by facilitating the formation of a " replication complex ".